Description

Dbco-Peg10-Dbco is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring terminal dibenzocyclooctyne (DBCO) groups. This compound is essential for facilitating strain-promoted azide-alkyne cycloaddition (SPAAC), a critical bioorthogonal click chemistry reaction that proceeds without the need for cytotoxic copper catalysts. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science for creating stable, well-defined conjugates of biomolecules, polymers, and nanoparticles.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: For site-specific coupling of cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides.
• PEGylation and Drug Delivery: As a functionalized PEG spacer to create stealth liposomes, polymeric micelles, and other nanocarriers to improve pharmacokinetics.
• Surface Functionalization and Biosensor Fabrication: For immobilizing biomolecules onto chips, beads, or other solid supports for diagnostic assays and sensor platforms.
• Hydrogel and Biomaterial Crosslinking: To form biocompatible networks for 3D cell culture, tissue engineering, and controlled release applications.
• Polymer Chemistry and Materials Science: As a building block for synthesizing functional block copolymers and smart materials with clickable handles.
• Chemical Biology and Proteomics: For labeling and pull-down experiments to study protein interactions, localization, and function in live cells.

Basic Information

Product Name	Dbco-Peg10-Dbco
CAS No.	2096516-12-8
Molecular Formula	C68H100N2O22
Molecular Weight	1297.5 g/mol (Theoretical)
Synonyms	DBCO-PEG10-DBCO; Bis-DBCO-PEG10; Dibenzocyclooctyne-PEG10-Dibenzocyclooctyne; DBCO-(PEG)10-DBCO; 1,11-Bis((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane-2,34-dione; Heterobifunctional PEG DBCO linker; SPAAC crosslinker; PEG-based DBCO homobifunctional linker.
EINECS	Contact for details

Quality Control

Our Dbco-Peg10-Dbco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.