Description

Dbco-Peg3-Amine is a heterobifunctional crosslinker featuring a dibenzocyclooctyne (DBCO) group and a primary amine, connected by a triethylene glycol (PEG3) spacer. This compound is essential for bioorthogonal click chemistry, enabling efficient, catalyst-free conjugation with azide-functionalized molecules under physiological conditions. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and the synthesis of advanced biomaterials and diagnostics.

Application

• Bioconjugation and ADC Development: Site-specific labeling of antibodies, proteins, peptides, and oligonucleotides via reaction with azide tags.
• Biomaterial Functionalization: Modification of hydrogels, nanoparticles, and surfaces for targeted drug delivery and tissue engineering applications.
• Diagnostic Probe Synthesis: Construction of fluorescent, radioactive, or affinity probes for imaging and detection assays.
• Chemical Biology Tool: For studying biomolecular interactions and cellular processes using bioorthogonal chemistry.
• Polymer and Dendrimer Synthesis: As a building block for creating functionalized, branched, or crosslinked polymeric structures.
• Small Molecule Drug Conjugation: Linking therapeutic payloads to targeting vectors for prodrug strategies.

Basic Information

Product Name	Dbco-Peg3-Amine
CAS No.	2093409-57-3
Molecular Formula	C26H30N2O4
Molecular Weight	434.53 g/mol
Synonyms	DBCO-PEG3-NH2; DBCO-PEG3-Amine; DBCO-PEG3-Amine; Dibenzocyclooctyne-PEG3-Amine; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)carbamate; Azadibenzocyclooctyne-PEG3-Amine; ADIBO-PEG3-NH2; DBCO-triethyleneglycol-amine
EINECS	Contact for details

Quality Control

Our Dbco-Peg3-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and reactivity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, methanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.