Description

Sulfo Dbco-Peg4-Amine is a heterobifunctional crosslinker featuring a water-soluble sulfonate group, a polyethylene glycol (PEG) spacer, and reactive DBCO and amine termini. This compound is engineered for efficient, copper-free click chemistry conjugation, offering enhanced solubility and reduced non-specific binding in aqueous biological systems. It is a critical reagent for researchers and developers in bioconjugation, ADC (Antibody-Drug Conjugate) development, and advanced biomaterial fabrication.

Application

• Bioconjugation and ADC Linker: For site-specific coupling of drugs, dyes, or other payloads to antibodies, proteins, or peptides via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Surface Functionalization: Modification of nanoparticles, biosensors, or microarray surfaces with amine-reactive chemistry for subsequent biomolecule immobilization.
• Hydrogel and Biomaterial Synthesis: As a crosslinking agent for creating PEG-based hydrogels with tailored mechanical properties and bioactivity.
• Diagnostic Probe Development: Construction of fluorescent or targeted imaging probes for in vitro and in vivo applications.
• Polymer Chemistry: Serving as a functional monomer or modifier to introduce clickable handles and hydrophilic PEG chains into polymer backbones.
• Chemical Biology Tool: For labeling and studying biomolecular interactions in live cells without cytotoxic copper catalysts.

Basic Information

Product Name	Sulfo Dbco-Peg4-Amine
CAS No.	2055198-05-3
Molecular Formula	C₃₃H₄₉N₃O₁₂S
Molecular Weight	711.82 g/mol
Synonyms	DBCO-PEG4-Amine, sulfonated; DBCO-PEG4-NH2, sulfonated; Sulfo-DBCO-PEG4-Amine; 3-[(1S,8S,9S)-16-Amino-4,7,10,13-tetraoxa-16-azahexadecyl]-11-[(1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethoxy]-6-oxo-6-(sulfooxy)hexyl 5-methyl-2,4,8,10-tetraoxa-6-aza-5-phosphadodecan-12-oate 5-oxide; DBCO-Sulfo-PEG4-Amine; Heterobifunctional PEG linker DBCO-PEG4-Amine-Sulfo; Azadibenzocyclooctyne-PEG4-Amine, sulfonated; Water-soluble DBCO-PEG-amine linker.
EINECS	Contact for details

Quality Control

Our Sulfo Dbco-Peg4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the material meets the high standards required for research and biopharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.