Description

E3 Ligase Ligand-Linker Conjugates 5 Free Base is a high-purity, advanced chemical building block specifically designed for the development of Proteolysis-Targeting Chimeras (PROTACs). This compound serves as a critical bifunctional linker, enabling the precise assembly of molecules that recruit E3 ubiquitin ligases to induce targeted protein degradation. It is an essential research tool for pharmaceutical developers, medicinal chemists, and academic researchers focused on novel therapeutic modalities in oncology, neurodegenerative diseases, and beyond. The product is supplied as a free base form to facilitate downstream synthetic modifications.

Application

• PROTAC Molecule Synthesis: A core component for constructing heterobifunctional degraders that link a target protein-binding warhead to an E3 ligase ligand.
• Drug Discovery Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for targeted protein degradation platforms.
• Chemical Biology Probes: Enables the creation of molecular tools to study protein function and validate new disease targets via the ubiquitin-proteasome system.
• Bioconjugation: The linker moiety can be utilized for conjugating various functional groups, peptides, or other ligands in advanced bioconjugation strategies.
• Preclinical Development: Supports the synthesis of candidate molecules for in vitro and in vivo efficacy and pharmacokinetic evaluation.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 5 Free Base
CAS No.	2010159-56-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker 5; E3 Ligase Ligand Conjugate 5; Degrader Building Block 5; Bifunctional PROTAC Linker; Targeted Protein Degradation Linker; (S,R,S)-AHPC-PEG2-C2-Cl; Cereblon Ligand-PEG2-Alkyne Conjugate (related class)
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 5 Free Base is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR/MS for structural confirmation. Certificates of Analysis (COA) detailing all test results are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.