Description

5'-o-Dmtr-2'-o-Moe-Ra(Bz) is a key phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound matters for its critical role in constructing RNA sequences with enhanced nuclease resistance and stability, which is fundamental for therapeutic and diagnostic applications. It is primarily needed by biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other advanced RNA-based therapeutics.

Application

• Solid-Phase Oligonucleotide Synthesis: As a building block for the automated synthesis of RNA strands.
• Therapeutic RNA Development: For the production of antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) drug candidates.
• Research Grade Oligonucleotides: Used in academic and industrial R&D for creating custom RNA probes and primers.
• Diagnostic Assay Components: Manufacture of RNA components for molecular diagnostics and biosensors.
• Scale-Up cGMP Manufacturing: Serves as a critical raw material in the cGMP production of oligonucleotide active pharmaceutical ingredients (APIs).
• Modified RNA Synthesis: Enables the incorporation of 2'-O-methoxyethyl (MOE) modifications to enhance pharmacokinetic properties.

Basic Information

Product Name	5'-o-Dmtr-2'-o-Moe-Ra(Bz)
CAS No.	251647-48-0
Molecular Formula	C46H51N4O9P
Molecular Weight	834.90 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine, 3'-[(2-Cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite, N6-Benzoyl-5'-O-DMT-2'-O-MOE-adenosine-3'-CE-phosphoramidite; 2'-MOE-A(Bz) Phosphoramidite; 5'-DMT-2'-MOE-Adenosine(Bz)-CE Phosphoramidite; 2'-O-(2-Methoxyethyl)adenosine Phosphoramidite; RNA Phosphoramidite Monomer
EINECS	Contact for details

Quality Control

Our 5'-o-Dmtr-2'-o-Moe-Ra(Bz) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can support production under cGMP guidelines for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.