Description

n-(9-((3R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-3-Yl)-9H-Purin-6-Yl)Benzamide CAS NO 215032-02-3 is a sophisticated nucleoside analog building block, specifically a protected adenine derivative, critical for advanced oligonucleotide synthesis. This compound is engineered to provide exceptional purity and structural integrity, which are non-negotiable for successful automated solid-phase synthesis. It is an essential raw material for research institutions and pharmaceutical manufacturers developing therapeutic oligonucleotides, including antisense drugs, siRNA, and aptamers.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a key phosphoramidite precursor for the controlled incorporation of modified adenine bases into DNA/RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and GMP-scale production of ASO drug candidates targeting genetic diseases.
• Small Interfering RNA (siRNA) Manufacturing: A critical building block for creating siRNA duplexes with enhanced stability and specificity for gene silencing applications.
• Aptamer Synthesis: Enables the production of structured nucleic acid aptamers for diagnostic and therapeutic targeting.
• Research-scale Nucleic Acid Chemistry: Provides a high-purity starting material for academic and industrial research into novel nucleoside modifications and their properties.
• GMP Manufacturing of Active Pharmaceutical Ingredients (APIs): Suitable for use in the regulated production of oligonucleotide-based APIs, adhering to stringent quality protocols.

Basic Information

Item	Details
Product Name	n-(9-((3R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-3-Yl)-9H-Purin-6-Yl)Benzamide
CAS No.	215032-02-3
Molecular Formula	C38H35N5O6
Molecular Weight	657.72 g/mol
Synonyms	6-Benzamidopurine DMT-protected nucleoside; N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine; DMT-dA-Bz Amidite precursor; N6-Benzoyl-5'-O-DMT-2'-deoxyadenosine; 2'-Deoxy-N6-benzoyladenosine, 5'-O-(4,4'-dimethoxytrityl)-; Protected deoxyadenosine derivative; DNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Every batch of this high-value building block is produced and tested under a strict quality management system. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for oligonucleotide synthesis. Certificates of Analysis (COA) with full traceability are provided for each lot, supporting development and regulatory filings from research through to GMP production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.