Description

4-Methoxyphenethylmagnesium Chloride is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis for the formation of carbon-carbon bonds. Its value lies in its ability to act as a nucleophile, efficiently introducing the 4-methoxyphenethyl moiety into target molecules, which is a key structural motif in pharmaceuticals and advanced materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to synthesize complex organic intermediates.

Application

• Key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing aryl-alkyl ether structures.
• Nucleophilic addition reactions to carbonyl compounds (aldehydes, ketones, esters) for alcohol synthesis.
• Building block for the preparation of liquid crystals and advanced organic electronic materials.
• Production of agrochemical intermediates, such as herbicides and fungicides.
• Laboratory-scale research and process development for novel chemical entities.
• Cross-coupling reactions in conjunction with transition metal catalysts.

Basic Information

Product Name	4-Methoxyphenethylmagnesium Chloride
CAS No.	211115-05-8
Molecular Formula	C9H11ClMgO
Molecular Weight	194.94 g/mol
Synonyms	2-(4-Methoxyphenyl)ethylmagnesium Chloride; 4-Methoxyphenethylmagnesium Chloride Solution; (4-Methoxyphenethyl)magnesium Chloride; p-Methoxyphenethylmagnesium Chloride; 1-Chloro-2-(4-methoxyphenyl)ethylmagnesium; Grignard Reagent, 4-Methoxyphenethylmagnesium Chloride; Magnesium, chloro[2-(4-methoxyphenyl)ethyl]-
EINECS	Contact for details

Quality Control

Our 4-Methoxyphenethylmagnesium Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Quality is verified through analytical techniques including titration for Grignard concentration, GC, and NMR analysis. A comprehensive Certificate of Analysis (COA) detailing concentration, solvent, and impurity profile is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Keep away from heat, sparks, open flames, and strong oxidizing agents. Use only in a well-ventilated area or fume hood.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	Typically 0.5 M to 2.0 M in THF or Diethyl Ether
Assay (Titration)	≥ 95% (as Grignard reagent)
Identification (IR/NMR)	Conforms to structure
Solvent	Specified (e.g., Tetrahydrofuran, Diethyl Ether)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.