Description

5-[E-2-[n-[6-(Trifluoroacetamido)Hexyl]Carboxamido]Vinyl]-5'- o-(4,4'-Dimethoxytrityl)-2'-Deoxyuridine, 3'-[(2-Cyanoethyl)-(N,n-Diisopropyl)]Phosphoramidite is a high-purity, specialty phosphoramidite monomer designed for automated oligonucleotide synthesis. This compound is critical for the controlled incorporation of modified nucleosides into synthetic DNA and RNA strands, enabling advanced research and therapeutic development. It is an essential raw material for pharmaceutical R&D, diagnostic assay developers, and academic institutions working on antisense oligonucleotides, aptamers, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: Key building block for the solid-phase synthesis of modified DNA strands on automated synthesizers.
• Therapeutic Nucleic Acid Development: Used in the research and production of antisense oligonucleotides (ASOs), siRNA, and aptamers for targeted therapies.
• Diagnostic Probe Manufacturing: Enables the creation of labeled and functionalized DNA probes for molecular diagnostics, including PCR and hybridization assays.
• Basic Research: Facilitates the study of nucleic acid structure, function, and protein interactions through site-specific modification.
• Bioconjugation: The reactive phosphoramidite group and side-chain modifications allow for the subsequent attachment of reporter molecules, peptides, or other functional groups.

Basic Information

Product Name	5-[E-2-[n-[6-(Trifluoroacetamido)Hexyl]Carboxamido]Vinyl]-5'- o-(4,4'-Dimethoxytrityl)-2'-Deoxyuridine, 3'-[(2-Cyanoethyl)-(N,n-Diisopropyl)]Phosphoramidite
CAS No.	210534-16-0
Molecular Formula	C55H64F3N5O10P
Molecular Weight	1042.09 g/mol
Synonyms	5-[E-2-[N-[6-(Trifluoroacetamido)hexyl]carboxamido]vinyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; dU-C6-Amino-TFA Phosphoramidite; 5-(3-Amino-1-propenyl)-2'-deoxyuridine C6-TFA Phosphoramidite; 5-[3-[N-[6-(Trifluoroacetamido)hexyl]carbamoyl]-1-propenyl]-2'-deoxy-5'-O-DMT-uridine 3'-CE phosphoramidite; Amino-Modifier C6 dT Phosphoramidite (TFA protected); 5-(3-Aminoprop-1-en-1-yl)-2'-deoxyuridine derivative phosphoramidite
EINECS	Contact for details

Quality Control

This high-value phosphoramidite is manufactured under strict quality control protocols to ensure batch-to-batch consistency and optimal coupling efficiency. Each lot is characterized by HPLC, 31P NMR, and 1H NMR to confirm identity, purity, and phosphitylation level. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and solvent residues is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade product quality and performance. Allow vials to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Moisture (Karl Fischer)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.