Description

N6-Bz-2'-o-4'-A-Locked-Ar-Ce-Phosphoramidite is a specialized, high-purity phosphoramidite monomer, a critical building block for the solid-phase synthesis of modified oligonucleotides. Its value lies in enabling the precise incorporation of a locked nucleic acid (LNA) adenine analogue, which significantly enhances the binding affinity and nuclease resistance of synthetic oligonucleotides. This product is essential for research and development in therapeutic antisense oligonucleotides (ASOs), siRNA, diagnostic probes, and advanced molecular biology applications where high-performance nucleic acid analogs are required.

Application

• Therapeutic Oligonucleotide Synthesis: Key monomer for manufacturing antisense oligonucleotides (ASOs) and siRNA therapeutics with improved stability and potency.
• Diagnostic Probe Development: Used to create high-affinity hybridization probes for PCR, FISH, and microarray technologies requiring superior specificity.
• Locked Nucleic Acid (LNA) Research: Fundamental reagent for academic and industrial research exploring the properties and applications of LNA-modified oligonucleotides.
• Aptamer and SELEX Technology: Enables the synthesis of nuclease-resistant nucleic acid libraries for the selection of high-performance aptamers.
• Synthesis of Conjugated Oligonucleotides: Serves as a precursor for creating oligonucleotides conjugated to reporter molecules or delivery agents.

Basic Information

Item	Details
Product Name	N6-Bz-2'-o-4'-A-Locked-Ar-Ce-Phosphoramidite
CAS No.	206055-79-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-O,4'-C-methyleneadenosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; LNA-A(Bz)-CE Phosphoramidite; 2'-O,4'-C-Methylene Adenosine Phosphoramidite (N6-Bz); Bz-A-LNA-CE Phosphoramidite; N6-Benzoyl-2'-O,4'-C-methyleneadenosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); LNA Adenine Phosphoramidite; Bicyclic Adenosine Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of N6-Bz-2'-o-4'-A-Locked-Ar-Ce-Phosphoramidite is manufactured under strict quality systems and undergoes comprehensive analytical testing to ensure it meets the exacting standards required for oligonucleotide synthesis. We provide a detailed Certificate of Analysis (COA) with each shipment, reporting key parameters such as purity (by HPLC), identity (by NMR and MS), and moisture content. Our quality commitment supports applications in GMP-grade therapeutic development and critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and strictly light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Freely soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.