Description

Dmtr-Lna-G(Ibu)-3'-Ced-Phosphoramidite is a specialized, high-purity phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound is critical for introducing locked nucleic acid (LNA) modifications, which significantly enhance the binding affinity and nuclease resistance of synthetic oligonucleotides. It is an essential building block for research and development in therapeutic antisense oligonucleotides, diagnostic probes, and advanced molecular biology tools.

Application

• Synthesis of Therapeutic Antisense Oligonucleotides (ASOs): Used to incorporate LNA-G monomers, creating high-affinity, stable drug candidates for targeting RNA in genetic diseases.
• Diagnostic Probe and Primer Design: Enables the production of highly specific and sensitive probes for PCR, FISH, and microarray applications.
• siRNA and miRNA Research: Serves as a key reagent for constructing chemically modified siRNA and miRNA mimics with improved pharmacokinetic properties.
• Aptamer Development: Integral for creating nuclease-resistant aptamers with high target affinity for diagnostic and therapeutic use.
• Basic Nucleic Acid Research: Provides a tool for studying nucleic acid structure, function, and stability through site-specific LNA incorporation.
• Good Manufacturing Practice (GMP) Grade Production: Suitable for scaling up to cGMP standards for the manufacture of clinical-grade oligonucleotide APIs.

Basic Information

Item	Detail
Product Name	Dmtr-Lna-G(Ibu)-3'-Ced-Phosphoramidite
CAS No.	206055-77-8
Molecular Formula	C46H57N6O8P
Molecular Weight	853.0 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O,4'-C-methylene-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-N2-isobutyrylguanosine; LNA-G(Ibu) Phosphoramidite; 2'-O,4'-C-Methylene Guanosine Phosphoramidite; Locked Nucleic Acid G Phosphoramidite; DMT-LNA-G-Phosphoramidite; 5'-DMT-2'-O,4'-C-methylene-N2-isobutyryl-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
EINECS	Contact for details

Quality Control

Our Dmtr-Lna-G(Ibu)-3'-Ced-Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for critical oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry-leading standards and can provide material suitable for research through to cGMP production upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) in a dedicated freezer. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.