Description

Poly(A-C) is a synthetic polynucleotide copolymer composed of alternating adenine and cytosine ribonucleotides. This compound serves as a critical research-grade biochemical for studying nucleic acid interactions, hybridization kinetics, and enzyme mechanisms. It is primarily utilized by biotechnology, pharmaceutical, and academic research institutions engaged in molecular biology, diagnostics development, and foundational biochemical research.

Application

• Molecular Biology Research: Used as a model template or substrate in studies of RNA polymerase activity, reverse transcription, and nucleic acid amplification techniques.
• Diagnostic Assay Development: Serves as a control or calibrator in the development of hybridization-based diagnostic tests, including blotting and microarray technologies.
• Enzymology Studies: Employed to investigate the specificity and kinetics of nucleases, polymerases, and other nucleic acid-modifying enzymes.
• Biophysical Characterization: Utilized in spectroscopic studies (UV, CD) to understand the structural properties and stability of alternating sequence RNA polymers.
• Teaching & Reference Standard: Acts as a defined-sequence polynucleotide for educational purposes and as a reference material in analytical laboratories.

Basic Information

Product Name	Poly(A-C)
CAS No.	29629-69-4
Molecular Formula	(C19H22N8O12P2)n
Molecular Weight	Variable (Polymer)
Synonyms	Polyadenylic-cytidylic acid; Poly r(A-C); Poly(A-C) homopolymer; Polyadenylate-cytidylate; Alternating Adenine-Cytosine Polymer; Polyriboadenylic-cytidylic acid; RNA Polymer (A-C); Poly rAC
EINECS	Contact for details

Quality Control

Our Poly(A-C) is produced under controlled conditions to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous analysis, including assessment of polymer length distribution, base composition, and absence of nucleases. A comprehensive Certificate of Analysis (COA) detailing purity, absorbance ratios (A260/A280), and physical state is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This material is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under desiccant.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (UV)	Characteristic absorption spectrum for polynucleotides
Identification (IR)	Spectrum consistent with structure
Assay (HPLC)	≥ 95% (as polynucleotide)
Base Ratio (A:C)	~1:1 (by HPLC or enzymatic digestion)
Absorbance Ratio (A260/A280)	2.0 - 2.2
Solubility	Soluble in aqueous buffers, TE buffer
Nuclease Activity	Not detected

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.