Description

Daunorubicinol Hcl is a key metabolite and derivative of the anthracycline antibiotic Daunorubicin. This compound is of significant interest in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the mechanisms of action of chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in oncology drug discovery and the development of analytical reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quality control and assay validation of Daunorubicin and related pharmaceutical products.
• Metabolite Research: Used in preclinical and clinical studies to investigate the metabolic pathways, efficacy, and toxicity profile of Daunorubicin chemotherapy.
• Biochemical Research: Employed as a tool compound in studies exploring the interaction of anthracyclines with DNA and topoisomerase II enzymes.
• Analytical Method Development: Essential for developing and calibrating sensitive analytical methods such as HPLC and LC-MS/MS for bioanalysis and pharmacokinetic studies.
• Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of Daunorubicin drug substances and formulations.

Basic Information

Product Name	Daunorubicinol Hcl
CAS No.	28008-53-9
Molecular Formula	C27H31NO11 • HCl
Molecular Weight	582.00 g/mol (for free base, C27H31NO11)
Synonyms	13-Dihydrodaunorubicin Hydrochloride; Daunorubicin Hydrochloride Impurity C (EP); Daunorubicinol Hydrochloride; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
EINECS	Contact for details

Quality Control

Our Daunorubicinol Hcl is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or quality control requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccant and under inert atmosphere if specified.

Specification

Item	Specification
Appearance	Reddish-orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.