Description

Poly(Ri).Poly(Dc) CAS NO 27380-19-4 is a synthetic double-stranded polynucleotide complex, widely utilized as a potent inducer of interferon and an activator of the innate immune response. Its primary commercial value lies in its critical role as a research reagent and a key component in the development of advanced therapeutics, including vaccines and immunomodulatory drugs. This product is essential for biotechnology and pharmaceutical companies, as well as academic research institutions focused on virology, immunology, and nucleic acid-based drug discovery.

Application

• Immunology Research: Used as a standard inducer of Type I interferons (IFN-α/β) in cell culture studies to model viral infection and immune activation.
• Vaccine Adjuvant Development: Serves as a model immunostimulant in preclinical research for evaluating novel adjuvant formulations to enhance vaccine efficacy.
• Antiviral Drug Screening: Employed in high-throughput screening assays to discover and validate new antiviral compounds that modulate the interferon pathway.
• Cell Signaling Studies: A key tool for investigating intracellular signaling cascades, particularly the TLR3 and RIG-I/MDA5 pathways.
• Diagnostic Reagent Manufacturing: Incorporated as a control or standard in diagnostic kits designed to measure interferon activity or immune response.
• Gene Expression Analysis: Used to stimulate cells for studying the expression profiles of interferon-stimulated genes (ISGs).

Basic Information

Product Name	Poly(Ri).Poly(Dc)
CAS No.	27380-19-4
Molecular Formula	(C10H13N5O6P)n • (C9H12N3O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Polyriboinosinic-polyribocytidylic acid; Poly(I:C); Poly I:C; Polyinosinic-polycytidylic acid; PIC; Poly I-poly C; Hiltonol® (brand name); Ampligen® (related analog); TLR3 Agonist; dsRNA analog
EINECS	Contact for details

Quality Control

Our Poly(Ri).Poly(Dc) is produced under stringent quality management systems. Each batch is rigorously tested to ensure identity, purity, and biological activity, meeting the exacting standards required for life science research. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as absorbance ratios (A260/A280), endotoxin levels, and functional activity in cell-based assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store as lyophilized powder; reconstituted solutions should be aliquoted and used immediately or stored at -80°C for short periods.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or fibrous solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Polymer Content)
Absorbance Ratio (A260/A280)	1.8 - 2.2
Endotoxin	< 10 EU/mg
Biological Activity (Cell-based assay)	Induces IFN-α at specified concentration
Solubility	Soluble in sterile, endotoxin-free water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.