Description

Poly Da-Dt CAS NO 26966-61-0 is a synthetic polynucleotide copolymer composed of alternating deoxyadenylate and deoxythymidylate residues. This well-defined oligomer is a critical reagent in molecular biology research, serving as a model substrate and primer for studying nucleic acid interactions and enzyme kinetics. It is essential for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic sectors who require high-purity, sequence-specific oligonucleotides for advanced applications.

Application

• Molecular Biology Research: Used as a standard template or primer in studies of DNA polymerase activity, fidelity, and processivity.
• Enzyme Assay Development: Serves as a defined substrate for the screening and characterization of nucleases, ligases, and other DNA-modifying enzymes.
• Diagnostic Probe Development: Acts as a component in the design and calibration of hybridization probes and biosensors.
• Biochemical Standard: Provides a reference material for spectroscopic analysis (e.g., UV melting curves) and chromatographic method development for oligonucleotides.
• Pharmaceutical R&D: Utilized in early-stage research for antisense oligonucleotide and gene therapy vector development.

Basic Information

Product Name	Poly Da-Dt CAS NO 26966-61-0
CAS No.	26966-61-0
Molecular Formula	(C10H14N5O7P • C10H15N2O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(deoxyadenylic-deoxythymidylic) acid; Poly(dA-dT); Poly(dA-dT) Helix; Alternating dA-dT copolymer; Poly(deoxyadenylate-thymidylate); DNA Copolymer (dA-dT)n; Oligo(dA-dT); Poly(dAdT)
EINECS	Contact for details

Quality Control

Our Poly Da-Dt is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for identity confirmation. Certificates of Analysis (COA) detailing purity, absorbance ratios (A260/A280), and molecular weight distribution are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation. For laboratory use only.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (UV)	Characteristic absorbance maximum at ~260 nm
Purity (HPLC)	≥ 95%
Absorbance Ratio (A260/A280)	1.8 - 2.0
Molecular Weight	Defined range (e.g., 10-20 mer) available
Endotoxin Level	< 10 EU/mg (upon request)
Solubility	Soluble in TE buffer or nuclease-free water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.