Description

Polyinosinic Acid (5') Potassium Salt is a synthetic, single-stranded polynucleotide composed of inosine monophosphate units. This compound serves as a critical research reagent and a key component in the development of advanced therapeutic and diagnostic platforms. It is primarily utilized by biotechnology, pharmaceutical, and life science research organizations for applications in immunology, virology, and molecular biology.

Application

• Immunological Research: Used as a synthetic analog of double-stranded RNA (dsRNA) to stimulate immune responses and study pattern recognition receptors like TLR3 and RIG-I.
• Vaccine Adjuvant Development: Investigated as a potent immunostimulant in vaccine formulations to enhance antigen-specific immune responses.
• Antiviral Studies: Employed in research to model viral infection mechanisms and to evaluate the efficacy of antiviral compounds.
• Cell Culture & In Vitro Diagnostics: Acts as a controlled stimulus in cell-based assays to induce interferon production and study cellular defense pathways.
• Biochemical Reagent: Serves as a standard or substrate in enzymatic assays and other biochemical research applications.
• Therapeutic Nucleic Acid Research: Used in the development and testing of novel RNA-based therapeutics and delivery systems.

Basic Information

Product Name	Polyinosinic Acid (5') Potassium Salt
CAS No.	26936-41-4
Molecular Formula	(C10H11N4O8PK)n
Molecular Weight	Contact for details
Synonyms	Poly(I) Potassium Salt; Polyinosinic Acid Potassium Salt; Poly I Potassium Salt; 5'-Inosinic Acid, Homopolymer, Potassium Salt; Poly(5'-inosinic acid) Potassium Salt; Polyinosinate Potassium; Potassium Polyinosinate; Poly I:K
EINECS	Contact for details

Quality Control

Our Polyinosinic Acid (5') Potassium Salt is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research-grade biochemicals. A Certificate of Analysis (COA) detailing specifications such as absorbance ratios (A250/A260, A280/A260), polynucleotide length, and potassium content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term stability, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms
Absorbance Ratio (A250/A260)	0.80 - 0.90
Absorbance Ratio (A280/A260)	0.15 - 0.25
Assay (HPLC)	≥ 95% (Polynucleotide Content)
Potassium Content	Contact for details
Solubility	Soluble in water, TE buffer
Biological Activity	Induces interferon production in appropriate cell lines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.