Description

Poly(U-G) CAS NO 26680-26-2 is a synthetic polynucleotide copolymer composed of uridylic and guanylic acid residues, serving as a critical research-grade biochemical. This product is essential for molecular biology and biochemistry research, particularly in studies involving RNA structure, hybridization, and enzyme kinetics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers for applications requiring a defined, synthetic RNA-like polymer.

Application

• Molecular Biology Research: Used as a template or substrate in studies of RNA-dependent enzymes like RNA polymerases, reverse transcriptases, and nucleases.
• Hybridization Studies: Serves as a synthetic RNA probe for developing and optimizing nucleic acid hybridization techniques and diagnostic assays.
• Biochemical Standard: Acts as a calibrated standard in chromatography (HPLC, SEC) and spectrophotometry for quantifying or characterizing nucleic acids.
• Vaccine & Therapeutic Development: Employed in early-stage research for mRNA vaccine platforms and oligonucleotide-based therapeutics to model RNA behavior.
• Enzyme Kinetics & Inhibition: Provides a defined polynucleotide backbone for investigating enzyme mechanisms and screening for potential antiviral or anticancer compounds that target RNA.
• Biophysical Studies: Used to analyze the thermal stability, secondary structure formation, and ligand-binding properties of RNA molecules.

Basic Information

Product Name	Poly(U-G) CAS NO 26680-26-2
CAS No.	26680-26-2
Molecular Formula	(C9H11N2O8P)n • (C10H12N5O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(uridylic-guanylic acid); Poly(U,G); Poly UG; Polyribouridylic-guanylic acid; U-G Copolymer; Poly(rU-rG); Polynucleotide copolymer (U,G); Synthetic RNA copolymer
EINECS	Contact for details

Quality Control

Our Poly(U-G) is manufactured under controlled conditions to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous analysis, including assessment of polymer length distribution, base composition ratio (U:G), and purity from protein and other polynucleotide contaminants. A comprehensive Certificate of Analysis (COA) detailing spectroscopic data, chromatographic profiles, and functional performance is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (UV-Vis)	Characteristic absorption spectrum for polynucleotides
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (as polynucleotide)
Base Ratio (U:G)	As specified per grade (e.g., 1:1)
Protein Content	≤ 0.1%
Ribonuclease Activity	Not detectable
Solubility	Soluble in sterile, nuclease-free water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.