Description

Poly(U-C) CAS NO 26427-29-2 is a synthetic polynucleotide copolymer composed of uridylic and cytidylic acid residues. This compound serves as a critical research-grade nucleic acid polymer, providing a defined template for studying RNA-dependent processes. It is essential for researchers and manufacturers in the fields of molecular biology, virology, and pharmaceutical development, particularly for applications involving RNA polymerase activity, antiviral screening, and diagnostic assay development.

Application

• RNA Polymerase Substrate & Template: Used as a defined synthetic template for studying the kinetics and specificity of viral and cellular RNA-dependent RNA polymerases (RdRPs).
• Antiviral Research: Serves as a substrate in high-throughput screening assays to identify and evaluate novel inhibitors of viral replication enzymes.
• Diagnostic Reagent Development: Employed in the development and calibration of molecular diagnostic kits that require synthetic RNA controls or standards.
• Biochemical Studies: Utilized to investigate nucleic acid hybridization, protein-RNA interactions, and the mechanisms of RNA interference (RNAi).
• Enzyme Standardization: Acts as a standard reagent for qualifying the activity of commercial enzyme preparations, such as reverse transcriptase.
• Academic & Pharmaceutical R&D: A fundamental tool in basic research for understanding RNA virus replication and in drug discovery pipelines targeting RNA viruses.

Basic Information

Product Name	Poly(U-C) CAS NO 26427-29-2
CAS No.	26427-29-2
Molecular Formula	(C9H11N2O8P • C9H12N3O8P)n
Molecular Weight	Variable (Polymer)
Synonyms	Polyuridylic-cytidylic acid; Poly(U-C) homopolymer; Poly r(U-C); Polyribouridylic-cytidylic acid; Uridine-Cytidine Copolymer; Poly(5'-Uridylic-5'-cytidylic acid); Poly(U)-Poly(C) Copolymer; Synthetic RNA Polymer U-C
EINECS	Contact for details

Quality Control

Our Poly(U-C) is produced under stringent conditions to ensure batch-to-batch consistency and high performance in sensitive research applications. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) are provided, detailing parameters such as polymer length distribution, base composition ratio (U:C), and absence of nucleases. We adhere to ISO 9001 quality management principles to guarantee reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (IR)	Conforms to structure
Assay (UV)	≥ 95% (as polynucleotide)
Base Ratio (U:C)	~1:1 (or as specified per lot)
Solubility	Soluble in aqueous buffers (e.g., TE buffer, nuclease-free water)
Absorbance Ratio (A260/A280)	2.0 - 2.2
Nuclease Activity	Not detected
Endotoxin	< 10 EU/mg (for research-grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.