Description

Polyadenylic Acid Potassium Salt is a synthetic, single-stranded homopolymer of adenosine monophosphate, widely utilized as a critical reagent in molecular biology and biochemistry. Its primary value lies in its role as a model RNA molecule and a versatile tool for enzymatic studies, particularly for poly(A) polymerase and reverse transcriptase assays. This high-purity biochemical is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors, enabling advancements in nucleic acid research, vaccine development, and bioprocess optimization.

Application

• Molecular Biology Research: Serves as a standard substrate and template for studying enzymes like poly(A) polymerase, reverse transcriptase, and RNases.
• Diagnostic Kit Manufacturing: Used as a key component in the production of kits for mRNA analysis and quantification.
• Vaccine Development: Acts as a model mRNA molecule in the research and development of mRNA-based vaccine platforms and delivery systems.
• Biochemical Assays: Employed in calibration standards and positive controls for various nucleic acid hybridization and amplification techniques (e.g., PCR, qPCR).
• Pharmaceutical R&D: Utilized in studies investigating RNA stability, degradation, and interactions with proteins or other biomolecules.
• Academic & Institutional Labs: A fundamental reagent for teaching and advanced research in genetics, virology, and cell biology.

Basic Information

Product Name	Polyadenylic Acid Potassium Salt
CAS No.	24937-83-5
Molecular Formula	(C10H12KN5O7P)n
Molecular Weight	Contact for details (Polymer)
Synonyms	Poly(A) Potassium Salt; Potassium Polyadenylate; Polyadenylic Acid, Potassium Salt; Poly A Potassium Salt; 5'-Adenylic Acid Homopolymer Potassium Salt; Polynucleotide Homopolymer (A); Poly rA Potassium Salt; Adenosine 5'-Monophosphate Homopolymer Potassium Salt
EINECS	Contact for details

Quality Control

Our Polyadenylic Acid Potassium Salt is manufactured under stringent controls to ensure batch-to-batch consistency and high performance. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, spectrophotometry for concentration verification, and enzymatic activity assays. A Certificate of Analysis (COA) detailing specifications for identity, purity, endotoxin levels, and biological activity is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 95% (Poly(A) content)
Absorbance Ratio (A260/A280)	2.0 - 2.2
pH (1% Solution)	6.5 - 8.0
Endotoxin	< 10 EU/mg
RNase Activity	Not detected
Water Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.