Description

n-Leucyldaunorubicin is a semi-synthetic derivative of the potent anthracycline antibiotic, daunorubicin, where an n-leucine moiety is conjugated to the parent compound. This structural modification is designed to potentially alter the pharmacokinetic profile, targeting, and therapeutic index of the molecule, making it a compound of significant interest in advanced pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology and novel drug delivery systems for the investigation of improved chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or derivative in the research and development of next-generation anthracycline-based chemotherapeutics.
• Biochemical Research: Used as a reference standard or active compound in studies investigating structure-activity relationships (SAR), metabolism, and resistance mechanisms of anthracycline drugs.
• Oncology R&D: Employed in in vitro and in vivo preclinical studies to evaluate enhanced efficacy, reduced cardiotoxicity, or improved tumor targeting compared to parent compounds.
• Prodrug Development: Investigated for its potential as a prodrug, where the leucine moiety may be cleaved by specific enzymes to release the active daunorubicin at the target site.
• API Development: Acts as an intermediate in the synthetic pathway for developing new Active Pharmaceutical Ingredients (APIs) with modified properties.

Basic Information

Product Name	n-Leucyldaunorubicin
CAS No.	23828-86-6
Molecular Formula	C41H53N3O15
Molecular Weight	827.87 g/mol
Synonyms	N6-(N-Leucyl)daunorubicin; Daunorubicin N-leucine derivative; Leucyldaunorubicin; L-Leucyl-daunorubicin; 3'-N-[(S)-4-Methyl-1-oxopentyl]daunorubicin; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9-[(2S)-4-methyl-1-oxopentan-2-yl]oxy-7,8,9,10-tetrahydrotetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our n-Leucyldaunorubicin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods such as HPLC and NMR. We are committed to meeting the stringent requirements of pharmaceutical R&D, and custom purity grades or analytical services are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices for light-sensitive compounds.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.