Description

Cyclopropylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its primary value lies in its ability to act as a potent nucleophile for the efficient formation of carbon-carbon bonds, introducing the cyclopropyl group into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, enabling the synthesis of complex molecules with cyclopropane rings for drug discovery and specialty chemical development.

Application

Cyclopropylmagnesium Bromide is a key building block in fine chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) containing cyclopropane motifs, which are common in various therapeutic agents.
• Agrochemical Synthesis: Production of herbicides, fungicides, and insecticides where the cyclopropyl group enhances biological activity.
• Material Science: Creation of novel monomers and polymers with unique physical properties for specialty materials.
• Cross-Coupling Reactions: Serving as a coupling partner in transition metal-catalyzed reactions like Kumada couplings to form new C-C bonds.
• Nucleophilic Addition: Reacting with carbonyl compounds (aldehydes, ketones, esters) to produce secondary and tertiary alcohols with cyclopropyl substituents.
• Asymmetric Synthesis: Used in the preparation of chiral compounds for the development of enantiomerically pure drugs and catalysts.

Basic Information

Product Name	Cyclopropylmagnesium Bromide
CAS No.	23719-80-4
Molecular Formula	C3H5BrMg
Molecular Weight	145.28 g/mol
Synonyms	Cyclopropylmagnesium bromide solution; Bromocyclopropane magnesium; Magnesium, bromocyclopropyl-; Cyclopropanemagnesium bromide; Grignard reagent, cyclopropylmagnesium bromide; (Cyclopropyl)magnesium bromide; Cyclopropyl magnesium bromide; Bromomagnesium cyclopropane
EINECS	Contact for details

Quality Control

Our Cyclopropylmagnesium Bromide is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistency, and reliability for your critical synthesis work. We provide comprehensive Certificates of Analysis (COA) with detailed specifications including assay, concentration, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines where applicable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, well-ventilated area. For solutions, store as recommended on the specific product label, typically at 2-8°C or under inert conditions at room temperature. Keep away from heat, sparks, open flames, and incompatible materials such as strong acids, oxidizers, and water.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration	Typically 0.5M to 2.0M in THF or Diethyl Ether
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.