Description

Guanine-8-3H Hydrochloride is a tritium-labeled derivative of the nucleobase guanine, specifically modified at the 8-position, and supplied as its hydrochloride salt. This compound is essential for high-sensitivity tracer studies in biochemical and pharmacological research, enabling precise tracking of metabolic pathways and nucleic acid interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers involved in advanced molecular biology, radiopharmaceutical development, and metabolic flux analysis.

Application

• Tracer Studies in Nucleic Acid Metabolism: Used to investigate the synthesis, turnover, and catabolism of purines and related nucleotides.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a radiolabeled tool compound for studying the absorption, distribution, metabolism, and excretion (ADME) of guanine-based pharmaceuticals.
• Enzyme Mechanism and Inhibition Studies: Employed in assays to elucidate the mechanisms of enzymes like guanine deaminase or purine nucleoside phosphorylase.
• Molecular Biology Research: Used in probing nucleic acid structure, function, and protein-nucleic acid interactions.
• Radiopharmaceutical Precursor: Acts as a potential starting material or intermediate in the synthesis of labeled diagnostic agents.
• Oncology and Virology Research: Applied in studies targeting purine salvage pathways in cancer cells or viral replication cycles.

Basic Information

Product Name	Guanine-8-3H Hydrochloride
CAS No.	23199-21-5
Molecular Formula	C5H53H ClN5O • HCl
Molecular Weight	~207.6 g/mol (for unlabeled Guanine HCl)
Synonyms	2-Amino-1,7-dihydro-6H-purin-6-one-8-3H Hydrochloride; [8-3H]Guanine Hydrochloride; 8-Tritio-guanine hydrochloride; Guanine-8-t Hydrochloride; 6H-Purin-6-one, 2-amino-1,7-dihydro-8-3H-, hydrochloride (1:1); Labeled Guanine HCl; Tritiated Guanine HCl
EINECS	Contact for details

Quality Control

Our Guanine-8-3H Hydrochloride is produced and handled under controlled conditions to ensure radiochemical purity and specific activity meet the stringent requirements of research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as radiochemical purity, chemical purity, specific activity, and solvent composition. We adhere to rigorous quality testing protocols to ensure consistency and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage of solutions, consider aliquoting and storing under inert atmosphere to minimize radiolytic decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	10-30 Ci/mmol (Contact for specific value)
Solvent (for solutions)	Ethanol/Water or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.