Description

Chloro[4-(Trifluoromethyl)Phenyl]Magnesium is a highly reactive organomagnesium compound, specifically a Grignard reagent, widely used as a versatile building block in organic synthesis. Its core value proposition lies in its ability to introduce the 4-(trifluoromethyl)phenyl group into target molecules, a moiety prized for its ability to modulate lipophilicity, metabolic stability, and binding affinity in advanced materials and pharmaceuticals. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylphenyl groups to enhance drug-like properties.
• Agrochemical Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a critical precursor for creating fluorinated aromatic cores in electronic display and lighting materials.
• Polymer & Specialty Chemical Manufacturing: Employed to incorporate fluorinated aromatic units into polymers, enhancing thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed cross-coupling reactions (e.g., Kumada coupling) for carbon-carbon bond formation.
• Nucleophilic Addition to Carbonyls: Used in classic Grignard reactions with ketones, aldehydes, and esters to create new carbon-carbon bonds and tertiary alcohols.

Basic Information

Product Name	Chloro[4-(Trifluoromethyl)Phenyl]Magnesium
CAS No.	2923-41-3
Molecular Formula	C7H4ClF3Mg
Molecular Weight	204.86 g/mol
Synonyms	(4-(Trifluoromethyl)phenyl)magnesium chloride; 4-(Trifluoromethyl)phenylmagnesium chloride; p-Trifluoromethylphenylmagnesium chloride; 1-Chloromagnesio-4-(trifluoromethyl)benzene; Magnesium, chloro[4-(trifluoromethyl)phenyl]-; Grignard Reagent (4-Trifluoromethylphenyl-MgCl)
EINECS	220-876-6

Quality Control

Our Chloro[4-(Trifluoromethyl)Phenyl]Magnesium is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including titration for active Grignard concentration and GC/HPLC analysis to confirm purity and identify potential impurities. A comprehensive Certificate of Analysis (COA) detailing concentration, solvent, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is highly volatile, easily oxidized, and reacts violently with water and protic solvents; it must be handled and stored in a dry, well-ventilated area away from moisture, acids, and oxidizers.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR/NMR)	Conforms to structure
Solvent	Tetrahydrofuran (THF) or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.