Description

2,4,6-Trimethylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its primary value lies in its ability to act as a powerful nucleophile and strong base for the formation of carbon-carbon bonds, a fundamental step in constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require high-purity intermediates for fine chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the mesityl (2,4,6-trimethylphenyl) group into target molecules during the research and development of new active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and pesticides where the mesityl moiety can enhance biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Material Science Research: Employed in the creation of novel organic electronic materials, such as those for OLEDs or organic semiconductors, by forming critical aryl-metal bonds.
• Fine Chemical Production: Utilized in custom and contract manufacturing for producing high-value, specialty chemicals that require precise aryl group incorporation.
• Academic & Industrial R&D: A staple reagent in laboratory-scale reactions for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	2,4,6-Trimethylphenylmagnesium Bromide
CAS No.	2633-66-1
Molecular Formula	C9H11BrMg
Molecular Weight	223.39 g/mol
Synonyms	Mesitylmagnesium Bromide; (2,4,6-Trimethylphenyl)magnesium Bromide; Magnesium, bromo(2,4,6-trimethylphenyl)-; Trimethylphenylmagnesium Bromide; MesMgBr; Grignard Reagent MesMgBr; Bromomesitylmagnesium; 2,4,6-Trimethylphenylmagnesium Bromide solution
EINECS	220-124-7

Quality Control

Every batch of our 2,4,6-Trimethylphenylmagnesium Bromide is manufactured and tested under stringent quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, concentration (typically supplied as a solution in THF or diethyl ether), and impurity profiles. Our quality assurance protocols are designed to meet the exacting standards required for GMP intermediates and research-grade chemicals, ensuring batch-to-batch consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and highly volatile. For optimal stability, store under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Keep away from heat, sparks, open flames, and strong oxidizers. Use only in a well-ventilated fume hood.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Identification (IR)	Conforms
Assay (Titration)	0.5 M to 2.0 M in THF or Et2O (as specified)
Purity (GC/HPLC)	≥ 95% (of Grignard reagent)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.