Description

N(6),N(6)-Dimethyladenylyl(3'-5')N(6),N(6)-Dimethyladenosine is a chemically modified dinucleotide, specifically a dimethylated adenosine dinucleotide. This compound is of significant value in biochemical and pharmaceutical research due to its role in studying RNA structure, function, and enzyme interactions. It is primarily required by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in nucleoside chemistry, oligonucleotide synthesis, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving RNA-modifying enzymes, methyltransferases, and nucleotidyltransferases.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of nucleoside-based therapeutics, including antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Acts as a building block or modified unit for the chemical synthesis of specialized oligonucleotides with tailored properties for diagnostic or therapeutic applications.
• Structural Biology: Employed in NMR and X-ray crystallography studies to understand the conformational impact of base methylation on RNA duplex stability and protein-RNA interactions.
• Diagnostic Probe Development: Utilized in the design and synthesis of labeled probes for detecting specific RNA sequences or methylation patterns.

Basic Information

Product Name	N(6),N(6)-Dimethyladenylyl(3'-5')N(6),N(6)-Dimethyladenosine
CAS No.	2273-75-8
Molecular Formula	C24H32N10O11
Molecular Weight	636.58 g/mol
Synonyms	N6,N6-Dimethyladenylyl-(3'→5')-N6,N6-dimethyladenosine; N6,N6-Dimethyl-A(3'-5')N6,N6-dimethyl-A; N6,N6-Dimethyladenosine(3'-5')N6,N6-dimethyladenosine; Dimethyladenosine Dinucleotide; Ap(m6A)m6A (alternate shorthand); 6,6'-Dimethyladenylyl(3'-5')-6,6'-dimethyladenosine; N6,N6-Dimethyladenosine 3'-5' cyclic dinucleotide (related form); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system suitable for supplying materials for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.