Description

Dexamethasone Isonicotinate is a potent synthetic glucocorticoid ester, combining the anti-inflammatory and immunosuppressive properties of dexamethasone with the isonicotinate moiety. This compound is of significant commercial and pharmaceutical interest for its targeted therapeutic applications and formulation stability. It is primarily required by manufacturers in the pharmaceutical and veterinary medicine industries for the development of specialized injectable and topical treatments.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of long-acting injectable corticosteroid preparations for treating severe inflammation, allergic disorders, and certain autoimmune conditions.
• Veterinary Medicine: Used in anti-inflammatory and anti-shock formulations for livestock and companion animals, often in depot injection forms for sustained effect.
• Ophthalmic Solutions: Serves as an active agent in eye drops and ointments for managing inflammatory ocular diseases.
• Dermatological Preparations: Incorporated into creams, ointments, and gels for treating severe skin conditions like psoriasis, eczema, and contact dermatitis.
• Research & Development: A critical reference standard and intermediate in pharmaceutical R&D for studying glucocorticoid receptor activity and developing new steroid-based therapies.
• Specialty Drug Delivery Systems: Utilized in the development of controlled-release and targeted drug delivery systems due to its esterified structure.

Basic Information

Product Name	Dexamethasone Isonicotinate
CAS No.	2265-64-7
Molecular Formula	C28H32FNO6
Molecular Weight	497.56 g/mol
Synonyms	Dexamethasone 21-Isonicotinate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Isonicotinate; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-(3-pyridinecarboxylate); Dexamethasone Nicotinate (common alias); DXM Isonicotinate; NSC 113927; SQ 15102; Isonicotinic acid, ester with dexamethasone.
EINECS	218-860-9

Quality Control

Our Dexamethasone Isonicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, identification by IR and NMR, and tests for residual solvents and heavy metals, to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	+77° to +83° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.