Description

Dspe-Peg-N3 CAS NO 1938081-39-0 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a terminal azide (N3) group. This molecular architecture is critical for constructing advanced drug delivery systems, enabling the precise conjugation of targeting ligands or therapeutic payloads via bioorthogonal click chemistry. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation liposomal formulations, antibody-drug conjugates (ADCs), and nanoparticle-based therapeutics.

Application

• Liposome and Lipid Nanoparticle (LNP) Functionalization: Serves as a key phospholipid-PEG component for creating stealth liposomes (PEGylated liposomes) with a reactive azide handle for subsequent surface modification.
• Targeted Drug Delivery Systems: Enables the site-specific attachment of targeting moieties (e.g., antibodies, peptides, folic acid) via copper-free click chemistry with DBCO or cyclooctyne-functionalized ligands.
• Conjugation of Payloads: The azide group allows for the efficient and stable coupling of various drug molecules, dyes, or probes to lipid-based carriers for combination therapies or theranostics.
• Surface Coating and Bioconjugation: Used to modify surfaces of nanoparticles or materials with a lipid-PEG layer, providing biocompatibility and a platform for further biofunctionalization.
• mRNA Vaccine and Gene Therapy Platforms: A vital material in the formulation of lipid nanoparticles (LNPs) used for encapsulating and delivering nucleic acids (mRNA, siRNA), where PEG-lipids control particle size and stability.
• Research and Diagnostic Tool Development: Employed in academic and industrial R&D for creating novel assay systems, imaging probes, and model membrane studies.

Basic Information

Product Name	Dspe-Peg-N3
CAS No.	1938081-39-0
Molecular Formula	CnHmN4OpP (Contact for exact formula based on PEG chain length)
Molecular Weight	Variable (dependent on PEG chain length, e.g., 2000, 3400, 5000 Da). Contact for details.
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)]; DSPE-PEG-Azide; DSPE-PEGn-N3; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-azide]; Phospholipid-PEG-Azide; Lipid-PEG-N3; Azido-PEG-DSPE; N-(Azido-PEG)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine
EINECS	Contact for details.

Quality Control

Our Dspe-Peg-N3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. Specifications are confirmed via advanced techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, substitution ratio, and critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to prevent condensation. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White or off-white solid/wax
Identification (NMR)	Complies
PEG Average Molecular Weight	As ordered (e.g., 2000, 3400, 5000 Da)
Purity (HPLC)	≥95%
Functional Substitution (Azide)	≥90%
Water Content (KF)	≤1.0%
Solvents (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.