Description

Methyltetrazine-Peg4-Amine CAS NO 1802908-05-9 is a heterobifunctional crosslinking reagent featuring a methyltetrazine group for bioorthogonal click chemistry and a terminal amine for further conjugation. This compound is essential for creating stable, site-specific bioconjugates under mild, physiological conditions. It is primarily needed by researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and chemical biology for applications such as antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component for constructing stable, cleavable, or non-cleavable linkers between monoclonal antibodies and cytotoxic payloads.
• Protein and Peptide Labeling: Enables site-specific modification of proteins, peptides, and other biomolecules via the amine-reactive group for subsequent tetrazine ligation.
• Surface Functionalization: Used to modify nanoparticles, microspheres, biosensor chips, and other solid supports for targeted binding and detection.
• Fluorescent Probe Synthesis: Acts as a building block for creating turn-on or turn-off fluorescent probes and imaging agents for in vitro and in vivo studies.
• Polymer Conjugation: Facilitates the attachment of bioactive molecules to polymer backbones for drug delivery systems and biomaterials.
• Diagnostic Reagent Development: Employed in the design of immunoassays and molecular diagnostic tools requiring specific, high-affinity binding.

Basic Information

Product Name	Methyltetrazine-Peg4-Amine
CAS No.	1802908-05-9
Molecular Formula	C23H38N6O5
Molecular Weight	478.59 g/mol
Synonyms	Methyltetrazine-PEG4-NH2; 3-Methyl-6-(1,2,4,5-tetrazin-3-yl)-1,2,4,5-tetrazine-PEG4-amine; 2,5,8,11-Tetraoxatetradecan-14-amine, 13-(6-methyl-1,2,4,5-tetrazin-3-yl)-; Methyl-Tz-PEG4-Amine; Amine-PEG4-Methyltetrazine; 3-Methyl-1,2,4,5-tetrazine-PEG4-amine; Methyltetrazine-PEG4-amine linker; Tetrazine-PEG4-NH2
EINECS	Contact for details

Quality Control

Our Methyltetrazine-Peg4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange viscous liquid or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.