Description

1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-2-Oxo-n-[[4-(1,2,4,5-Tetrazin-3-Yl)Phenyl]Methyl]-, (3As,4S,6Ar)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a tetrazine moiety. This compound is of significant value for its role as a key building block in the synthesis of novel bioactive molecules, particularly in the development of targeted therapies and diagnostic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, bioconjugation chemistry, and the development of antibody-drug conjugates (ADCs).

Application

• Bioconjugation Linker: Serves as a critical component for site-specific conjugation of payloads (e.g., drugs, dyes, toxins) to biomolecules like antibodies, proteins, or peptides via bioorthogonal click chemistry.
• Antibody-Drug Conjugate (ADC) Development: Used in the research and synthesis of next-generation ADCs, enabling the creation of targeted cancer therapeutics with improved efficacy and reduced side effects.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes, enzyme activity, and protein function in live cells.
• Pharmaceutical Intermediate: Acts as a sophisticated building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• PET Imaging Agent Precursor: Utilized in the development of precursors for Positron Emission Tomography (PET) tracers, leveraging the tetrazine group for rapid radiolabeling.
• Materials Science Research: Investigated for potential applications in creating functionalized polymers or smart materials with specific chemical reactivity.

Basic Information

Product Name	1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-2-Oxo-n-[[4-(1,2,4,5-Tetrazin-3-Yl)Phenyl]Methyl]-, (3As,4S,6Ar)-
CAS No.	1714123-51-9
Molecular Formula	C17H18N8O2S
Molecular Weight	398.44 g/mol
Synonyms	(3aS,4S,6aR)-Hexahydro-2-oxo-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]-1H-thieno[3,4-d]imidazole-4-pentanamide; Tetrazine-PEG4-Biotin conjugate precursor; Biotin-tetrazine linker intermediate; 3-(4-(Aminomethyl)phenyl)-1,2,4,5-tetrazine conjugated biotin derivative; TCO-reactive biotin analog intermediate; Bioorthogonal biotin labeling reagent intermediate; SDA 001 (research code); CAS 1714123-51-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent ISO 9001:2015 quality management standards. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Specifications can be tailored to meet specific research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.