Description

3'-Tbdms-Ibu-Rg Phosphoramidite is a specialized, high-purity building block used in the automated solid-phase synthesis of oligonucleotides. This compound matters because it enables the precise and efficient incorporation of a modified ribose sugar moiety, which is critical for developing advanced therapeutic nucleic acids and research probes. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense oligonucleotides, siRNA, and other next-generation genetic medicines.

Application

• Oligonucleotide Synthesis: Key monomer for the automated synthesis of modified RNA strands on solid support.
• Therapeutic Nucleic Acid Development: Production of antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) for targeted gene silencing therapies.
• Research Probe Manufacturing: Creation of labeled and modified oligonucleotide probes for diagnostic assays and fundamental molecular biology research.
• Apitamer Discovery: Synthesis of chemically modified RNA libraries for Systematic Evolution of Ligands by Exponential Enrichment (SELEX) processes.
• Structural Biology Studies: Incorporation of specific sugar modifications to study RNA structure, stability, and protein interactions.

Basic Information

Product Name	3'-Tbdms-Ibu-Rg Phosphoramidite
CAS No.	1445905-51-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-[2-[[(2R,3R,4R,5R)-5-[2-Amino-6-(2-methylpropylamino)purin-9-yl]-3-[(tert-butyldimethylsilyl)oxy]-4-hydroxyoxolan-2-yl]methoxy-(diisopropylamino)phosphanyl]oxyethyl]pyrrole-2,5-dione; 3'-O-TBDMS-Ibu-rG Phosphoramidite; 3'-O-(tert-Butyldimethylsilyl)-N2-isobutyl-guanosine Phosphoramidite; N2-Isobutyl-2'-deoxy-3'-O-TBDMS-guanosine Phosphoramidite; Ibu-rG(TBDMS) Phosphoramidite; Guanosine, N-(2-methylpropyl)-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-deoxy-, 5'-[2-[[bis(1-methylethyl)amino]](1-oxido-2,5-pyrrolidinedion-1-yloxy)phosphino]oxyethyl] hydrogen phosphonate
EINECS	Contact for details

Quality Control

Our 3'-Tbdms-Ibu-Rg Phosphoramidite is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for critical pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) with detailed specifications are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.