Description

Pc Mal-Nhs Carbonate Ester CAS NO 1408057-91-9 is a specialized bifunctional linker molecule containing both a maleimide (Mal) group and an N-hydroxysuccinimide (NHS) ester, activated via a carbonate ester linkage. This compound is critical for creating stable, site-specific bioconjugates, enabling the precise attachment of biomolecules like antibodies, peptides, or drugs to carriers, surfaces, or other functional entities. It is primarily utilized by researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science where controlled covalent bonding is required.

Application

• Antibody-Drug Conjugate (ADC) Payload Linkage: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies for targeted cancer therapies.
• Protein and Peptide Labeling: Covalent attachment of fluorescent dyes, biotin, or other probes for imaging, detection, and diagnostic applications.
• Surface Functionalization: Immobilization of biomolecules onto nanoparticles, biosensors, microarrays, and other solid supports for assay development.
• Polymer Modification: Introduction of bioactive groups into polymer backbones to create functional biomaterials for drug delivery and tissue engineering.
• Cross-linking Agent: For creating stable bridges between molecules containing thiol (-SH) and amine (-NH2) functional groups.
• Diagnostic Reagent Synthesis: Key intermediate in the production of enzyme conjugates and other reagents used in ELISA and lateral flow assays.

Basic Information

Product Name	Pc Mal-Nhs Carbonate Ester
CAS No.	1408057-91-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG-NHS Carbonate; NHS-PEG-Mal Carbonate Ester; Polycarbonate Mal-NHS Ester; Bifunctional PEG Linker Mal-NHS; N-(Maleimidocarbonyloxy)succinimide PEG derivative; SM(PEG) Carbonate; Heterobifunctional Crosslinker with NHS and Maleimide; NHS-Carbonate-PEG-Maleimide
EINECS	Contact for details

Quality Control

Our Pc Mal-Nhs Carbonate Ester is produced under stringent conditions to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and functional group assay. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system to support our customers in GMP-compliant and research-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Maleimide)	≥ 90% of theoretical
Functional Group Assay (NHS Ester)	≥ 90% of theoretical
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.