Description

Dbco-Maleimide CAS NO 1395786-30-7 is a heterobifunctional crosslinking agent that combines a dibenzocyclooctyne (DBCO) group with a maleimide moiety. This compound is essential for bioorthogonal click chemistry, enabling rapid, catalyst-free, and selective conjugation under mild physiological conditions. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and advanced materials science, facilitating the precise labeling and functionalization of biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Linker: For site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Enables the attachment of fluorophores, PEG chains, or other probes via thiol-maleimide chemistry followed by strain-promoted azide-alkyne cycloaddition (SPAAC).
• Surface Functionalization: Used to modify nanoparticles, biosensors, and microarray surfaces for specific biomolecule capture.
• Polymer and Hydrogel Synthesis: Acts as a crosslinker for creating functionalized biomaterials with tailored properties.
• Diagnostic Reagent Development: Key component in the synthesis of probes for immunoassays and molecular imaging.
• Biomolecule Immobilization: For the stable attachment of proteins, antibodies, or oligonucleotides onto solid supports.

Basic Information

Product Name	Dbco-Maleimide
CAS No.	1395786-30-7
Molecular Formula	C24H19N3O4
Molecular Weight	413.43 g/mol
Synonyms	DBCO-Maleimide; DBCO-MAL; Dibenzocyclooctyne-Maleimide; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)carbamate; 1-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; Maleimide-PEG4-DBCO; DBCO-PEG4-Maleimide; Azadibenzocyclooctyne-Maleimide
EINECS	Contact for details

Quality Control

Our Dbco-Maleimide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and biopharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.