Description

Biotin-Peg4-Amino-T-Bu-Dadps-C6-Azide is a sophisticated, multifunctional chemical building block designed for advanced bioconjugation and linker applications. This compound integrates biotin for affinity capture, a tetraethylene glycol (PEG4) spacer for enhanced solubility, a tert-butyl-protected amino group, a sulfonamide-based DADPS moiety, a C6 alkyl chain, and a terminal azide for click chemistry. It is a critical reagent for researchers and developers in the life sciences sector who require precise and stable linkages in complex molecular assemblies. Its primary value lies in enabling the creation of targeted probes, drug conjugates, and diagnostic platforms with high specificity and efficiency.

Application

• ADC (Antibody-Drug Conjugate) Development: Serves as a cleavable or non-cleavable linker-payload component, connecting cytotoxic agents to targeting antibodies.
• Proteomics and Biomarker Discovery: Used to create biotinylated probes for the enrichment, isolation, and identification of proteins and other biomolecules via streptavidin pull-down assays.
• Diagnostic Assay Development: Facilitates the construction of detection platforms, such as ELISA or lateral flow assays, by conjugating signaling molecules to antibodies or antigens.
• Chemical Biology and Probe Design: Enables site-specific labeling of biomolecules (proteins, nucleic acids) through copper-free or copper-catalyzed azide-alkyne cycloaddition (Click Chemistry).
• Drug Delivery Systems: Functions as a key component in the design of targeted nanoparticle or liposome-based delivery vehicles for therapeutic agents.
• Materials Science and Surface Functionalization: Used to modify surfaces (e.g., chips, beads) with biotin for subsequent immobilization of streptavidin-conjugated molecules.

Basic Information

Product Name	Biotin-Peg4-Amino-T-Bu-Dadps-C6-Azide
CAS No.	1260247-50-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Biotin-PEG4-Amine-Tert-Butyl-DADPS-C6-N3; Biotin-PEG4-NH-TBDADPS-C6-N3; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(2-(3-(4-((tert-butoxycarbonyl)amino)phenyl)sulfonamido)propoxy)ethoxy)ethoxy)ethoxy)ethyl)pentanamide; Azido-PEG4-DADPS(Boc)-Biotin; Biotinylated DADPS-PEG4-azide linker; Boc-NH-DADPS-PEG4-Biotin-N3
EINECS	Contact for details

Quality Control

Our Biotin-Peg4-Amino-T-Bu-Dadps-C6-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and functional group analysis to ensure performance in conjugation reactions. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are provided with every shipment to support your research and development traceability requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Integrity (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.