Description

3'-o-Amino-2'-Deoxyadenosine 5'-Triphosphate is a chemically modified nucleotide triphosphate analog designed for advanced molecular biology and biochemical research. This compound is critical for applications requiring the site-specific introduction of amino-functionalized nucleotides, enabling precise labeling and cross-linking strategies. It is primarily utilized by researchers and manufacturers in the fields of next-generation sequencing (NGS) probe development, nucleic acid diagnostics, and oligonucleotide synthesis for therapeutic and diagnostic purposes.

Application

• Next-Generation Sequencing (NGS): Used in the enzymatic synthesis of amino-modified DNA probes and primers for targeted sequencing and microarray applications.
• Diagnostic Assay Development: Essential for creating labeled nucleotides used in PCR, qPCR, and other amplification-based diagnostic tests.
• Oligonucleotide Therapeutics: Serves as a building block for synthesizing modified antisense oligonucleotides (ASOs) and siRNA constructs with enhanced stability and targeting capabilities.
• Bioconjugation and Labeling: The primary amino group facilitates covalent attachment to fluorophores, biotin, or other reporter molecules for imaging and detection.
• Structural Biology Studies: Employed in X-ray crystallography and NMR to study protein-nucleic acid interactions via cross-linking.
• Enzymology Research: Used as a substrate to study the kinetics and specificity of DNA polymerases and other nucleic acid-processing enzymes.

Basic Information

Product Name	3'-o-Amino-2'-Deoxyadenosine 5'-Triphosphate
CAS No.	1220515-87-6
Molecular Formula	C10H16N6O12P3
Molecular Weight	529.18 g/mol
Synonyms	3'-Amino-2'-deoxyATP; 3'-NH2-dATP; 3'-Amino-2'-deoxyadenosine-5'-triphosphate; Amino-modified dATP; 2'-Deoxy-3'-aminoadenosine-5'-triphosphate; 3'-Amino-2'-deoxyadenosine triphosphate; 3'-Amino-dATP; 3'-Amino-2'-deoxy-ATP
EINECS	Contact for details

Quality Control

Our production of 3'-o-Amino-2'-Deoxyadenosine 5'-Triphosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is thoroughly characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Triethylammonium Salt Content	≤ 10%
Biological Activity (Enzymatic Incorporation)	Suitable for use

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.