Description

4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Benzamide is a specialized diazirine-based photoaffinity labeling reagent. This compound matters for its ability to form covalent bonds with biological targets upon activation with UV light, enabling the study of protein-ligand interactions and molecular binding sites. It is primarily needed by researchers and developers in pharmaceutical discovery, chemical biology, and proteomics for creating irreversible probes and mapping biological pathways.

Application

• Photoaffinity Labeling (PAL): As a critical reagent for covalent cross-linking in target identification and validation studies.
• Chemical Proteomics: For profiling protein functions and discovering novel drug targets within complex biological systems.
• Bioconjugation & Probe Development: In the synthesis of activity-based probes (ABPs) for visualizing enzyme activity.
• Drug Discovery Research: To study ligand-receptor interactions and characterize binding pockets with high precision.
• Material Science Research: Potential use in surface functionalization and creating light-responsive polymeric materials.

Basic Information

Product Name	4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Benzamide
CAS No.	1216997-96-4
Molecular Formula	C9H6F3N3O
Molecular Weight	229.16 g/mol
Synonyms	4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzamide; 4-(3-Trifluoromethyl-3H-diazirin-3-yl)benzamide; Benzamide, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-; 1216997-96-4; 4-(3-(Trifluoromethyl)diazirin-3-yl)benzamide; TPD-Benzamide; Trifluoromethylphenyl Diazirine Benzamide; Photoaffinity Labeling Reagent 1216997-96-4
EINECS	Contact for details

Quality Control

Our production of 4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Benzamide adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. Due to its hygroscopic and strictly light-sensitive nature, the container should be allowed to reach room temperature in a desiccator before opening to minimize moisture uptake and photodegradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.