Description

5'-Amino-Dt Cep CAS NO 194034-71-4 is a high-purity, nucleoside-based building block essential for advanced oligonucleotide synthesis. This compound matters for its role as a key intermediate in the development of therapeutic nucleic acids, including antisense oligonucleotides and aptamers. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CROs specializing in genetic medicine and molecular diagnostics.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for targeted gene silencing therapies.
• Aptamer Production: Enables the creation of specific, high-affinity nucleic acid aptamers for diagnostic and therapeutic applications.
• siRNA and miRNA Research: Serves as a modified nucleotide component in small interfering RNA (siRNA) and microRNA (miRNA) constructs to enhance stability and efficacy.
• Molecular Probes and Diagnostics: Incorporated into labeled probes for fluorescence in situ hybridization (FISH), PCR, and other detection assays.
• Bioconjugation: The amino group provides a handle for conjugation with fluorophores, quenchers, or other functional molecules.

Basic Information

Product Name	5'-Amino-Dt Cep
CAS No.	194034-71-4
Molecular Formula	C14H19N3O7
Molecular Weight	341.32 g/mol
Synonyms	5'-Amino-5'-deoxythymidine; 5'-Amino-2'-deoxythymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 5'-Amino-dT; Amino-modified deoxythymidine; 5'-NH2-dT
EINECS	Contact for details

Quality Control

Every batch of 5'-Amino-Dt Cep is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications suitable for pharmaceutical research applications. A detailed Certificate of Analysis (COA), including HPLC purity, identity confirmation (NMR, MS), and impurity profile, is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.