Description

5-Fluoro-2-Methoxyphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, used for the formation of carbon-carbon bonds in complex organic synthesis. Its value lies in its ability to introduce the 5-fluoro-2-methoxyphenyl moiety into target molecules, a key structural feature in advanced pharmaceutical and agrochemical intermediates. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to build novel fluorinated aromatic compounds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluoro-methoxyphenyl group contributes to biological activity and selectivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers and liquid crystals with specific electronic or optical properties.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions (e.g., Kumada coupling) to construct biaryl structures prevalent in many functional molecules.
• Nucleophilic Addition Reactions: Reacts with carbonyl compounds (aldehydes, ketones, esters) and epoxides to form new alcohols and extended carbon chains.
• Contract Research & Manufacturing (CRAM): A critical reagent for custom synthesis and scale-up services offered to the life sciences industry.

Basic Information

Product Name	5-Fluoro-2-Methoxyphenylmagnesium Bromide
CAS No.	188132-02-7
Molecular Formula	C7H6BrFMgO
Molecular Weight	229.33 g/mol
Synonyms	(5-Fluoro-2-methoxyphenyl)magnesium bromide; 2-Methoxy-5-fluorophenylmagnesium bromide; 5-Fluoro-2-methoxybenzene magnesium bromide; 5-Fluoro-o-anisylmagnesium bromide; Grignard reagent, (5-fluoro-2-methoxyphenyl)magnesium bromide; Magnesium, bromo(5-fluoro-2-methoxyphenyl)-
EINECS	Contact for details

Quality Control

Every batch of our 5-Fluoro-2-Methoxyphenylmagnesium Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. Quality is verified through comprehensive analytical testing, including titration for Grignard concentration and GC/HPLC analysis for solvent and impurity profiles. We provide full traceability and a Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality management system supports cGMP and ISO standards for reliable, consistent supply to critical industries.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended stability. The container should be kept in a cool, dry, well-ventilated area away from incompatible materials such as moisture, acids, and oxidizing agents. Always refer to the Safety Data Sheet (SDS) for complete handling and storage instructions.

Specification

Item	Specification
Appearance	Clear to slightly colored solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom)
Assay (Titration)	≥ 95%
Purity (GC/HPLC)	Contact for details
Solvent	Specified (Tetrahydrofuran, Diethyl ether, etc.)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.