Description

N6-Bz-5'-o-Dmtr-3'-o-Methyladenosine-2'-o-Ced-Phosphoramidite is a highly specialized, protected phosphoramidite monomer used in the solid-phase synthesis of oligonucleotides. This compound is critical for ensuring high coupling efficiency and sequence fidelity during automated nucleic acid assembly. It is an essential raw material for research institutions and manufacturers developing therapeutic oligonucleotides, diagnostic probes, and synthetic genes.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key building block for the automated synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Production: For the manufacture of antisense oligonucleotides, siRNA, and aptamers for pharmaceutical applications.
• Diagnostic Probe Fabrication: Used in creating labeled probes for genomic testing, fluorescence in situ hybridization (FISH), and microarray technologies.
• Synthetic Biology: Enables the construction of custom gene fragments and non-natural nucleic acid analogs for research and development.
• Antisense Research: A critical reagent in academic and industrial labs studying gene function and regulation.
• Scale-Up GMP Manufacturing: Suitable for use in Good Manufacturing Practice (GMP) environments for the production of clinical-grade oligonucleotides.

Basic Information

Product Name	N6-Bz-5'-o-Dmtr-3'-o-Methyladenosine-2'-o-Ced-Phosphoramidite
CAS No.	179479-02-8
Molecular Formula	C58H67N6O11P
Molecular Weight	1055.16 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(cyanomethyl)ethyl]-N6-benzoyl-3'-O-methyladenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-Ced Phosphoramidite of 5'-O-DMTr-3'-O-methyl-N6-benzoyladenosine; 3'-O-Methyladenosine Phosphoramidite; N6-Benzoyl-2'-O-(cyanomethyl)ethyl-3'-O-methyl-5'-O-(4,4'-dimethoxytrityl)adenosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 2'-O-Ced-A(Bz)-3'-O-Me-5'-O-DMTr Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of our phosphoramidite monomers is produced and tested under stringent quality systems to ensure high purity and reliable performance in sensitive oligonucleotide synthesis. We employ advanced analytical techniques, including HPLC and NMR, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and functional performance is provided with each shipment. Our quality commitment supports compliance with ISO standards and the requirements of GMP-oriented customers.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.