Description

3- Bis(Trime-Silyl)Amino!Phe-Magnesium is a highly specialized organometallic reagent featuring a unique silyl-protected amino magnesium structure. This compound matters for its role as a powerful and selective nucleophile in advanced organic synthesis, particularly for the formation of carbon-carbon and carbon-heteroatom bonds under mild conditions. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular construction for complex molecule synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the introduction of functionalized aromatic and heterocyclic groups in active pharmaceutical ingredient (API) development.
• Cross-Coupling Reactions: Used as a Grignard-type reagent in Kumada, Negishi, and related cross-coupling methodologies to construct biaryl and complex alkyl-aryl systems.
• Nucleophilic Addition: Employed in additions to carbonyl compounds (aldehydes, ketones, esters) and imines for the synthesis of amino alcohols and amines.
• Polymer & Material Science: Serves as a monomer or initiator in the synthesis of specialty polymers and functionalized silicon-containing materials.
• Agrochemical Research: Utilized in the preparation of novel herbicide and pesticide candidates requiring specific aromatic amine frameworks.
• Ligand & Catalyst Preparation: Acts as a precursor for the synthesis of novel nitrogen-containing ligands for transition metal catalysis.

Basic Information

Product Name	3- Bis(Trime-Silyl)Amino!Phe-Magnesium
CAS No.	174484-84-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3-[Bis(trimethylsilyl)amino]phenylmagnesium; [3-[Bis(trimethylsilyl)amino]phenyl]magnesium; 3-(N,N-Bis(trimethylsilyl)amino)phenylmagnesium; 3-Aminophenylmagnesium derivative, TMS-protected; N,N-Bis(trimethylsilyl)-3-aminophenylmagnesium; Grignard reagent of 3-[Bis(trimethylsilyl)amino]benzene
EINECS	Contact for details

Quality Control

Every batch of 3- Bis(Trime-Silyl)Amino!Phe-Magnesium is manufactured and handled under stringent inert atmosphere conditions to prevent degradation. Our products undergo rigorous quality testing, including titration for active magnesium content and spectroscopic analysis, to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) with batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated area. Due to its highly volatile and easily oxidized nature, the container must remain sealed under positive pressure of inert gas and only be accessed in a controlled, moisture-free environment.

Specification

Item	Specification
Appearance	Solution (typically in THF or Ether)
Concentration	0.5 M - 1.0 M in solvent
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.