Description

(7S,9S)-9-Acetyl-7-[(2S,4S,5S,6S)-4-Aziridin-1-Yl-6-Methyl-5-Methylsulfonyloxy-Oxan-2-Yl]Oxy-6,9,11-Trihydroxy-8,10-Dihydro-7H-Tetracene-5,12-Dione is a structurally complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture, featuring an aziridine ring and a tetracene-dione core, makes it a critical building block for the synthesis of novel therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of next-generation anti-cancer and antibiotic drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel anthracycline and tetracycline analogs for oncology research.
• Anticancer Drug Discovery: Used as a core scaffold in medicinal chemistry programs aimed at developing new chemotherapeutic agents with targeted mechanisms of action.
• Antibiotic Research: Employed in the synthesis of advanced tetracycline derivatives to combat antibiotic-resistant bacterial strains.
• Biochemical Tool Compound: Utilized in academic and industrial laboratories to study DNA intercalation and topoisomerase inhibition mechanisms.
• Process Chemistry Development: Acts as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions for Active Pharmaceutical Ingredient (API) production.

Basic Information

Product Name	(7S,9S)-9-Acetyl-7-[(2S,4S,5S,6S)-4-Aziridin-1-Yl-6-Methyl-5-Methylsulfonyloxy-Oxan-2-Yl]Oxy-6,9,11-Trihydroxy-8,10-Dihydro-7H-Tetracene-5,12-Dione
CAS No.	171047-47-5
Molecular Formula	C28H31NO11S
Molecular Weight	589.62 g/mol
Synonyms	9-Acetyl-7-[(4-aziridin-1-yl-6-methyl-5-(methylsulfonyloxy)oxan-2-yl)oxy]-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; Aziridinyl daunorubicin derivative; 4'-O-Acetyl-4-demethoxy-3'-N-trifluoroacetyl-4'-epidoxorubicin intermediate; 4-Demethoxy-7-O-(4-aziridinyl-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)adriamycinone derivative; Key intermediate for MEN 10755; (7S,9S)-9-Acetyl-4-demethoxy-7-[(2S,4S,5S,6S)-5-[(methylsulfonyl)oxy]-4-(aziridin-1-yl)-6-methyl-2-oxanyl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our (7S,9S)-9-Acetyl-7-[(2S,4S,5S,6S)-4-Aziridin-1-Yl-6-Methyl-5-Methylsulfonyloxy-Oxan-2-Yl]Oxy-6,9,11-Trihydroxy-8,10-Dihydro-7H-Tetracene-5,12-Dione is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development with custom synthesis and analytical method development to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange-red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.