Description

4-Fluorophenethylmagnesium Bromide is a highly reactive Grignard reagent, a cornerstone intermediate in modern synthetic organic chemistry. Its value lies in its ability to efficiently introduce the 4-fluorophenethyl moiety, enabling the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize active pharmaceutical ingredients (APIs), novel crop protection agents, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated organic semiconductors and liquid crystal molecules used in display technologies.
• Cross-Coupling Reactions: Employed in Kumada and other transition metal-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Nucleophilic Addition: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters) and epoxides.
• Fine Chemical & Flavor/Fragrance Intermediate: Facilitates the synthesis of complex fluorinated aromatic compounds for specialty chemical applications.

Basic Information

Product Name	4-Fluorophenethylmagnesium Bromide
CAS No.	157977-55-4
Molecular Formula	C8H8FMgBr
Molecular Weight	227.36 g/mol
Synonyms	2-(4-Fluorophenyl)ethylmagnesium Bromide; p-Fluorophenethylmagnesium Bromide; (4-Fluorophenethyl)magnesium Bromide; 4-Fluoro-phenethylmagnesium Bromide; Magnesium, bromo[2-(4-fluorophenyl)ethyl]-; Grignard Reagent (4-Fluorophenethyl); 4-F-PhenethylMgBr
EINECS	Contact for details

Quality Control

Our 4-Fluorophenethylmagnesium Bromide is produced under stringent quality control protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as concentration, titration assay, and impurity profile. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This reagent is typically supplied and stored as a solution in tetrahydrofuran (THF) or diethyl ether under an inert atmosphere (argon or nitrogen) to prevent degradation and ensure stability. Store at 2-8°C for prolonged shelf life. Handle and store away from moisture, heat, and incompatible materials such as strong acids, oxidizers, and protic solvents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow
Concentration	0.5 M in THF or Et2O (Custom concentrations available)
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.