Description

3 4 5-Trifluorophenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for introducing the 3,4,5-trifluorophenyl moiety into complex molecular frameworks. Its value lies in enabling efficient carbon-carbon bond formation, a critical step in the synthesis of advanced pharmaceutical intermediates and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing fluorinated aromatic compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating active pharmaceutical ingredients (APIs) with fluorinated aromatic rings, enhancing metabolic stability and bioavailability.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the trifluorophenyl group contributes to efficacy and environmental persistence.
• Liquid Crystal & OLED Material Production: Serves as a precursor for fluorinated organic semiconductors and liquid crystal compounds used in display technologies.
• Polymer Modification: Incorporates fluorinated phenyl groups into polymer chains to alter surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed reactions (e.g., Kumada coupling) for biaryl synthesis.
• Fine Chemical & Specialty Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for high-value, fluorinated fine chemicals.

Basic Information

Product Name	3 4 5-Trifluorophenylmagnesium Bromide
CAS No.	156006-28-9
Molecular Formula	C6H2F3MgBr
Molecular Weight	235.29 g/mol
Synonyms	Magnesium, bromo(3,4,5-trifluorophenyl)-; (3,4,5-Trifluorophenyl)magnesium bromide; 3,4,5-Trifluorophenylmagnesium bromide solution; 3,4,5-Trifluorophenyl Grignard reagent; 3,4,5-Trifluorobenzene, bromomagnesio-; 1-Bromo-3,4,5-trifluorobenzene magnesium derivative; Grignard reagent 3,4,5-F3C6H2MgBr
EINECS	Contact for details

Quality Control

Our 3 4 5-Trifluorophenylmagnesium Bromide is produced under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for assay determination and GC analysis for solvent and impurity profiling, to ensure consistency and high reactivity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing concentration, purity, and solution integrity. Our quality commitment aligns with cGMP principles for pharmaceutical applications, ensuring reliable supply and traceability for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. This product is typically supplied as a solution in diethyl ether or tetrahydrofuran. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize degradation and maintain reactivity. Due to its highly volatile and pyrophoric nature, keep away from heat, sparks, open flames, and oxidizing agents. Use only in a well-ventilated fume hood with appropriate safety equipment.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration	0.5 M in THF or Et2O (Custom concentrations available)
Assay (by Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.