Description

Dmt-Dc(Ac) Phosphoramidite is a high-purity, nucleoside phosphoramidite monomer essential for automated oligonucleotide synthesis. This compound is a critical building block for the precise and efficient assembly of DNA and RNA sequences. It is primarily required by biotechnology, pharmaceutical, and diagnostic industries for applications in therapeutic development, genetic research, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: As a key monomer for the solid-phase synthesis of DNA and RNA strands in automated synthesizers.
• Therapeutic Development: For the production of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.
• Research & Diagnostics: In the manufacture of primers, probes, and gene fragments for PCR, sequencing, and diagnostic assays.
• Synthetic Biology: For constructing custom genetic circuits, genes, and other synthetic nucleic acid constructs.
• Bioconjugation: As a starting material for creating labeled or modified oligonucleotides with specific functional groups.

Basic Information

Product Name	Dmt-Dc(Ac) Phosphoramidite
CAS No.	154110-40-4
Molecular Formula	C41H49N4O8P
Molecular Weight	756.83 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxycytidine, 3'-[(2-Cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite, N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite, dC(Ac) Phosphoramidite, Ac-dC Phosphoramidite, DMT-dC(Ac)-CE Phosphoramidite, 2'-Deoxycytidine Phosphoramidite Derivative
EINECS	Contact for details

Quality Control

Our Dmt-Dc(Ac) Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive synthesis workflows. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis and 31P NMR verification, to meet the stringent requirements of oligonucleotide production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic and moisture-sensitive nature, the product should be handled in a controlled, dry atmosphere and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (31P NMR)	Conforms
Purity (HPLC)	≥ 98.5%
Moisture (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.