Description

Oligodeoxyadenylic Acid D(Pa)2 Sodium Salt is a chemically modified oligonucleotide, specifically a dimer of deoxyadenylic acid with a phosphoramidate (Pa) linkage. This modification is critical for enhancing nuclease resistance and altering the physicochemical properties of the oligonucleotide backbone for advanced research and development applications. It serves as a fundamental building block for molecular biologists and pharmaceutical researchers working on antisense therapeutics, diagnostic probes, and synthetic biology platforms.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Used as a modified nucleotide precursor to create oligonucleotides with enhanced stability and binding affinity for therapeutic target validation.
• Diagnostic Probe Development: Serves as a key component in the construction of sensitive and specific hybridization probes for pathogen detection and genetic analysis.
• Nucleic Acid Chemistry Research: A vital reagent for studying the structure-activity relationships of modified oligonucleotides, particularly those with non-standard phosphoramidate backbones.
• Synthetic Biology & DNA Nanotechnology: Employed in the assembly of novel DNA nanostructures and synthetic genetic circuits where altered chemical properties are required.
• Bioconjugation & Labeling: Acts as a starting material for the site-specific attachment of reporter molecules, peptides, or other functional groups to oligonucleotides.
• Primer & Template Engineering: Utilized to introduce specific modifications into primers or templates for specialized PCR applications and sequencing studies.

Basic Information

Product Name	Oligodeoxyadenylic Acid D(Pa)2 Sodium Salt
CAS No.	149665-16-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	d(Pa)2 Sodium Salt; dA-Pa-dA Sodium Salt; Deoxyadenylyl-(3'→5')-deoxyadenosine Phosphoramidate Dimer Sodium Salt; Bis-deoxyadenylic Acid Phosphoramidate Sodium Salt; Oligo(dA)2 Phosphoramidate; DNA Dimer Phosphoramidate; Adenine Oligonucleotide Dimer Modified
EINECS	Contact for details

Quality Control

Every batch of Oligodeoxyadenylic Acid D(Pa)2 Sodium Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol is designed to meet the stringent requirements of research and pre-clinical development. Certificates of Analysis (COA) detailing specifications such as purity (HPLC), identity (MS, NMR), and moisture content are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Moisture Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.