Description

Rna "C" Phosphoramidite is a high-purity, nucleoside phosphoramidite monomer specifically designed for the solid-phase synthesis of RNA oligonucleotides. This critical building block enables the precise and efficient incorporation of cytidine into synthetic RNA strands, which is fundamental for research and therapeutic development. It is an essential raw material for biotechnology, pharmaceutical, and diagnostic companies engaged in RNA research, antisense technology, and the production of siRNA, miRNA, and mRNA therapeutics.

Application

• Solid-Phase RNA Synthesis: As a key monomer for the automated chemical synthesis of RNA oligonucleotides on DNA/RNA synthesizers.
• Therapeutic RNA Production: Manufacturing of siRNA (small interfering RNA), miRNA (microRNA), and antisense oligonucleotides for therapeutic applications.
• Research Reagent: Synthesis of custom RNA probes, primers, and standards for molecular biology and biochemical research.
• Diagnostic Development: Production of RNA components for diagnostic assays, biosensors, and next-generation sequencing platforms.
• CRISPR Guide RNA Synthesis: Chemical synthesis of guide RNA (gRNA) sequences for CRISPR-Cas gene editing systems.
• Aptamer Development: Construction of RNA aptamer libraries for drug discovery and target identification.

Basic Information

Item	Detail
Product Name	Rna "C" Phosphoramidite
CAS No.	149559-88-6
Molecular Formula	C47H57N6O8P
Molecular Weight	865.0 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N4-benzoyl-2'-O-[(tert-butyldimethylsilyl)]-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Cytidine Phosphoramidite (2'-O-TBDMS protected); RNA C Phosphoramidite; 2'-O-TBDMS-C(Bz) Phosphoramidite; N4-Benzoyl-5'-O-DMT-2'-O-TBDMS-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; RNA Building Block C; CE Phosphoramidite (Cytidine)
EINECS	Contact for details

Quality Control

Our Rna "C" Phosphoramidite is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to cGMP principles where applicable to support our customers in regulated pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic and easily oxidized nature, the product should be brought to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.