Description

N6-Dimethylaminomethylidene-2'-Deoxyisoguanosine is a sophisticated nucleoside analog derivative, primarily utilized as a key intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of modified oligonucleotides and potential therapeutic agents targeting genetic and viral diseases. It is essential for research institutions, biotechnology firms, and pharmaceutical companies engaged in antiviral drug discovery, nucleic acid chemistry, and the development of novel diagnostic probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Oligonucleotide Synthesis: Used in the research and development of modified DNA/RNA strands for antisense and siRNA therapeutic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Probe Development: Acts as a precursor for labeled nucleotides used in diagnostic assays and molecular biology techniques.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside analogs.

Basic Information

Product Name	N6-Dimethylaminomethylidene-2'-Deoxyisoguanosine
CAS No.	146196-17-0
Molecular Formula	C13H18N6O4
Molecular Weight	322.32 g/mol
Synonyms	2'-Deoxy-N6-(dimethylaminomethylene)isoguanosine; 2'-Deoxyisoguanosine, N6-(dimethylaminomethylene)-; N6-(Dimethylaminomethylene)-2'-deoxyisoguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[(dimethylamino)methylidene]amino]-1H-purin-2-one
EINECS	Contact for details

Quality Control

Our N6-Dimethylaminomethylidene-2'-Deoxyisoguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.