Description

8-Chloroadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is a chemically modified, stereospecific analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical research. This compound is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA), making it an indispensable tool for dissecting complex intracellular signaling pathways. It is primarily utilized by researchers and scientists in the fields of pharmacology, molecular biology, and neuroscience to study cellular regulation and develop novel therapeutic strategies.

Application

• Biochemical Research: As a selective PKA inhibitor to study cAMP-mediated signal transduction mechanisms.
• Pharmacological Studies: For investigating the role of PKA in disease models, including cardiac function, memory, and metabolic disorders.
• Neuroscience: Used in research on synaptic plasticity, neurotransmitter release, and neuronal excitability.
• Cell Biology: A critical tool for modulating intracellular cAMP levels to understand cell cycle control and differentiation.
• Drug Discovery: Serves as a reference standard and probe compound in high-throughput screening for novel kinase inhibitors.
• Academic & Institutional Research: Fundamental reagent for universities and research institutes conducting cutting-edge life science studies.

Basic Information

Product Name	8-Chloroadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt
CAS No.	142754-27-6
Molecular Formula	C10H10ClN5O5PSNa
Molecular Weight	429.70 g/mol
Synonyms	Rp-8-Chloro-cAMPS Sodium Salt; (Rp)-8-Chloroadenosine-3',5'-cyclic monophosphorothioate sodium salt; 8-Cl-cAMPS, Rp-isomer, sodium salt; cAMP antagonist, Rp-8-Cl-cAMPS; Adenosine, 8-chloro-3',5'-cyclic hydrogen phosphorothioate, Rp-isomer, sodium salt; PKA Inhibitor, Rp-8-Cl-cAMPS; Rp-8-Chloro-cyclic adenosine monophosphorothioate sodium salt
EINECS	Contact for details

Quality Control

Our 8-Chloroadenosine-3',5'-Cyclic Monophosphorothioate, Rp-Isomer Sodium Salt is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.