Description

3-(2-Tetrahydro-2H-Pyranoxy)Phenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its core value lies in enabling the precise and efficient introduction of the 3-(tetrahydropyran-2-yloxy)phenyl moiety, a valuable protected phenolic building block, into target molecular frameworks. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing complex drug candidates, particularly those containing substituted aromatic or heterocyclic systems.
• Agrochemical Active Ingredient Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific phenolic ether architectures.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and material science.
• Advanced Material Research: Employed in the creation of monomers and polymers with tailored properties for electronic or optical applications.
• Academic & Contract Research: A vital tool in academic laboratories and CROs (Contract Research Organizations) for methodological development and exploratory synthesis.
• Fine Chemical Production: Used in the multi-step synthesis of high-value, low-volume specialty chemicals and flavors/fragrances intermediates.

Basic Information

Product Name	3-(2-Tetrahydro-2H-Pyranoxy)Phenylmagnesium Bromide
CAS No.	142402-62-8
Molecular Formula	C11H15BrMgO2
Molecular Weight	283.44 g/mol
Synonyms	3-(2-Tetrahydropyranyloxy)phenylmagnesium bromide; (3-(Oxan-2-yloxy)phenyl)magnesium bromide; 3-(Tetrahydro-2H-pyran-2-yloxy)benzenemagnesium bromide; 3-(THP-Oxy)phenylmagnesium bromide; Grignard Reagent from 3-Bromophenol THP Ether; Magnesium, bromo[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-; [3-(2H-Pyran-2-yloxy)phenyl]magnesium bromide (tetrahydro-); 3-(2H-Pyran-2-yloxy)phenylmagnesium bromide, tetrahydro-
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Tetrahydro-2H-Pyranoxy)Phenylmagnesium Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. Our products undergo rigorous quality testing, including titration for Grignard concentration and analysis of key impurities, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing concentration, solvent, and assay is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures (typically 2-8°C for extended stability). The container should be kept in a cool, dry, well-ventilated area, separate from strong acids and oxidizing agents. Always handle and aliquot using strict air-free techniques.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Typical)
Assay (by Titration)	≥ 95% (of stated concentration)
Identification (IR/NMR)	Conforms to structure
Solvent	Tetrahydrofuran (THF) or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.