Description

Dmt-Di Phosphoramidite CAS NO 141684-35-7 is a high-purity, protected phosphoramidite monomer essential for automated oligonucleotide synthesis. This compound is a critical building block for constructing DNA and RNA sequences with precision and high coupling efficiency. It is primarily required by biotechnology, pharmaceutical, and diagnostic industries for applications in antisense therapy, PCR primers, probes, and next-generation sequencing.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of DNA and RNA strands in automated synthesizers.
• Therapeutic Oligonucleotides: Manufacturing of antisense oligonucleotides (ASOs), siRNA, and aptamers for drug development.
• Diagnostic Probes & Primers: Production of labeled and unlabeled probes and primers for PCR, qPCR, and molecular diagnostics.
• Research & Development: Synthesis of custom oligonucleotides for academic and industrial research in genomics and molecular biology.
• Next-Generation Sequencing (NGS): Fabrication of oligonucleotide libraries and adapters used in sequencing platforms.
• Bio-conjugation & Labeling: Intermediate for introducing functional groups or labels at specific sites within an oligonucleotide chain.

Basic Information

Product Name	Dmt-Di Phosphoramidite
CAS No.	141684-35-7
Molecular Formula	C41H51N2O7P
Molecular Weight	714.84 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyinosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); DMT-dI Phosphoramidite; 2'-Deoxyinosine Phosphoramidite, DMT-protected; dI Phosphoramidite; 5'-DMT-2'-deoxyinosine-3'-CE-phosphoramidite; Deoxyinosine Phosphoramidite; Inosine Phosphoramidite; 141684-35-7
EINECS	Contact for details

Quality Control

Our Dmt-Di Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC purity and 31P NMR analysis, to confirm identity and reactivity. Certificates of Analysis (COA) with full specification data are provided and we support compliance with relevant quality frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.