Description

Peptide Nucleic Acid, T10-Lysine CAS NO 139166-85-1 is a synthetic, sequence-specific biopolymer analog where the sugar-phosphate backbone of DNA is replaced by a pseudopeptide structure of N-(2-aminoethyl)glycine units, with a decathymine (T10) sequence and a lysine modification. This unique structure provides exceptional binding affinity and specificity for complementary DNA or RNA sequences, along with high biological stability and resistance to enzymatic degradation. It is a critical research tool and a promising candidate for advanced therapeutic and diagnostic applications in biotechnology, molecular biology, and pharmaceutical development.

Application

• Molecular Diagnostics: Used as a high-affinity probe in FISH (Fluorescence In Situ Hybridization), microarray analysis, and PCR clamping for the specific detection of genetic sequences.
• Therapeutic Antisense/Oligonucleotide Development: Serves as a backbone for antisense and antigene agents due to its superior stability and binding properties compared to traditional DNA/RNA analogs.
• Biosensor and Nano-assembly: Employed in the construction of highly specific biosensors and as a building block in DNA nanotechnology and nanostructure assembly.
• Pre-PCR Processing: Acts as a catcher molecule to remove PCR inhibitors or to selectively enrich target DNA from complex samples.
• Basic Research: A vital tool for studying gene expression, nucleic acid interactions, and for developing novel gene regulation strategies in academic and industrial R&D.
• Drug Delivery Systems: The lysine modification facilitates conjugation and can be utilized in creating targeted delivery vehicles for therapeutic nucleic acids.

Basic Information

Product Name	Peptide Nucleic Acid, T10-Lysine
CAS No.	139166-85-1
Molecular Formula	C54H84N30O18
Molecular Weight	1417.42 g/mol
Synonyms	PNA T10-Lys; Lys-T10 PNA; Decathyminyl PNA-Lysine conjugate; N-(2-Aminoethyl)glycine Peptide Nucleic Acid (T10) Lysine; PNA oligomer T10 with C-terminal lysine; H-Lys-T(TTTTTTTTTT)-NH2 (PNA sequence); Poly-T PNA Lysine amide
EINECS	Contact for details

Quality Control

Our Peptide Nucleic Acid, T10-Lysine is manufactured under strict quality systems. Each batch is characterized using advanced analytical techniques including HPLC and Mass Spectrometry to ensure high purity and sequence integrity. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight Verification (MS)	1417.42 ± 2 Da
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.