Description

2,8-Diazidoadenosine 5'-Triphosphate is a chemically modified nucleotide analog, specifically an azido-functionalized derivative of adenosine triphosphate (ATP). This compound is of significant value for its role as a versatile chemical probe and crosslinking agent in advanced biochemical and biophysical research. It is primarily needed by researchers and developers in the fields of nucleic acid chemistry, photochemistry, and chemical biology for applications such as photoaffinity labeling and the study of nucleotide-binding proteins.

Application

• Photoaffinity Labeling: Acts as a critical reagent for covalently tagging and identifying ATP-binding sites in proteins and enzymes upon UV irradiation.
• Chemical Crosslinking Studies: Used to investigate protein-nucleic acid interactions and map molecular binding interfaces.
• Bioconjugation and Probe Synthesis: Serves as a key building block for creating functionalized nucleotides via click chemistry, leveraging the reactive azide groups.
• Enzymology Research: Employed as a substrate analog to study the mechanism and kinetics of kinases, ATPases, and other nucleotide-dependent enzymes.
• Structural Biology: Aids in the structural analysis of macromolecular complexes through crosslinking mass spectrometry (XL-MS) techniques.
• Development of Diagnostic Tools: Potential use in the design of novel assays and sensors for detecting specific enzymatic activities.

Basic Information

Product Name	2,8-Diazidoadenosine 5'-Triphosphate
CAS No.	137705-53-4
Molecular Formula	C10H12N10O13P3
Molecular Weight	573.17 g/mol
Synonyms	2,8-Diazido-ATP; 2,8-Di-N3-ATP; 2,8-Diazidoadenosine-5'-triphosphate; N2,N8-Diazidoadenosine 5'-triphosphate; 2,8-Bis(azido)adenosine triphosphate; Azido-ATP; Diazido ATP; 5'-ATP-2,8-diazide
EINECS	Contact for details

Quality Control

Our 2,8-Diazidoadenosine 5'-Triphosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards to meet the exacting requirements of the research and pharmaceutical development communities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.